In adolescents with PCOS, an imbalance between androgens, anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) has been reported; the process of follicular development is characterized by relative luteinizing hormone (LH) increase, promoting androgen production [5,6] and inadequate FSH secretion, leading to a decreased conversion of androgen to estradiol and follicular growth arrest [7]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.