It should be noted that some authors described that even PCOS patients without overt hyperandrogenism showed gonadotropin derangement and had lower mean sex-hormone-binding globulin (SHBG) values than controls did, a finding that suggests abnormalities in insulin levels, probably related to the higher waist circumference values of this PCOS group compared to controls [92]. This evidence concerns the gene SHBG and hyperandrogenism.