Thus, isoform-selective inhibitors of HDAC8, such as PCI34051, PCI-34058, ITF3056 (givinostat), N-hydroxy-3-[1-(phenylthio) methyl-1H-1,2,3-triazol-4-yl]benzamide (NCC149) derivatives etc. [185,186,187] could provide the possible therapeutic options in T2DM by improving insulin sensitivity. The gene discussed is INS; the disease is type 2 diabetes mellitus.