Aucubin, a naturally occurring glycoside, can reduce oxidative stress and inflammation in renal tissue of T2D rats by endorsing Nrf2 and FOXO3a activation and suppressing NF-κB signalling, which has been proposed to be mediated through the activation of SIRT1 and SIRT3 [225]. This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.