HDAC3 can bind to the C/EBP homologous protein (Chop) and activating transcription factor 4 (Atf3) promoters in response to hyperlipidemia associated with T2DM and can induce apoptosis to β cells by endorsing endoplasmic reticulum (ER) stress [80]. This evidence concerns the gene DDIT3 and type 2 diabetes mellitus.