SIRT1 has also been found to inhibit hyperglycemia-provoked apoptosis in endothelial cells in vitro by inhibiting mitochondrial fission factor (Mff)-mediated mitochondrial fission, suppressing c-Jun N-terminal kinase (JNK) activation, and sustaining F-actin homeostasis [294]. The gene discussed is MFF; the disease is Hyperglycemia.