RGFP966, a specific inhibitor of HDAC3, was found to abrogate the initiation of diabetic cardiomyopathy by endorsing dual-specificity phosphatase 5 (DUSP5) activation by acetylating histone H3 on the DUSP5 primer region leading to an extracellular-signal-regulated kinase (Erk)1/2 activation [150]. The gene discussed is DUSP5; the disease is diabetic cardiomyopathy.