3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methyl pyridin-2-yl)-benzamide, a glucokinase activator useful in attenuating hyperglycemia associated with T2DM in mice, can prevent cytokine-provoked β cell apoptosis via SIRT1 activation [172]. This evidence concerns the gene SIRT1 and Hyperglycemia.