Retinal SIRT3 activation has been implicated in the protection of retinal capillary endothelial cells against hyperglycemia-induced damage in vitro and in vivo by endorsing redox defence via deacetylating manganese superoxide dismutase (MnSOD) and suppression of poly (ADP-ribose) polymerase [266]. The gene discussed is SIRT3; the disease is Hyperglycemia.