NOS3 and diabetic kidney disease: HDACs regulate the development and progression of diabetic nephropathy by maintaining acetylation balance on chromatin remodelling and regulating the transcription of genes [211] Long-term oral treatment of SAHA, a pan-HDACi, was found to reduce glomerular hypertrophy, mesangial collagen IV deposition, and albuminuria in diabetic mice by suppressing endothelial nitric oxide synthase (eNOS)-mediated oxidative stress [214].