Therefore, in our previous research we focused on evaluating the serum concentrations of several circulating HCs, including stem cell factor (SCF), granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interleuln-3 (IL-3), in patients with CRC in comparison to subjects with benign lesions of the colon (colorectal adenomas—CA), and healthy volunteers, in order to establish their diagnostic and prognostic value as well as to investigate a potential role played by these proteins in the pathogenesis of CRC [18,19,20,21]. This evidence concerns the gene CSF1 and colorectal carcinoma.