Therefore, in our previous studies, which utilized the fast and easy-to-use ELISA method, we compared the clinical significance of both gelatinases (MMP-9 and MMP-2) as well as their tissue inhibitors (TIMP1 and TIMP-2, respectively) in the diagnosis of CRC as well as in the differentiation between CA and CRC. This evidence concerns the gene TIMP2 and colorectal carcinoma.