TP53 and non-small cell lung carcinoma: In this study, we examined the impact of two different MFR regimens, fraction dose escalation (FDE) in the split course and the conventional hypofractionation (HF), on the phenotypic and molecular signatures of two IR surviving NSCLC cell sublines derived from parental A549 (p53 wild-type) and H1299 (p53-null) cells.