Especially, FGF2 treatment inhibited Aβ production in primary cultured neurons of APP/PS1 mice and APPswe-HEK293 cells [170,171] and improved synaptic transduction, plasticity, and neurogenesis in an APP/PS1 mouse, while reducing hippocampal Aβ deposition and memory impairment [170]. This evidence concerns the gene PSEN1 and memory impairment.