While the phosphomimetic (148D) HspB4/αA-crystallin overexpressing MGCs (HspB4−/−) showed a greater reduction of the “diabetes-like” stress-induced pro-inflammatory mediators evaluated, the non-phosphorylatable (148A) HspB4/αA-crystallin mutant was completely devoid of the dampening effect (Figure 3A–D). This evidence concerns the gene CRYAA and diabetes mellitus.