Individuals who test positive for RA biomarkers including ACPA, RF, and research biomarkers such as T-cell clones [71], anti-carbamylated protein (anti-CarP) and anti-peptidyl-arginine deiminase type-3 (anti-PAD3) antibodies [72], may also be at increased risk for RA or exacerbated disease activity and joint damage. Here, PRTN3 is linked to rheumatoid arthritis.