MYD88 and neoplasm: Currently, reverse transcription quantitative PCR (RT-qPCR) and panel next generation sequencing (NGS) are the techniques most often applied for the detection of MYD88 mutations [44], although samples containing a concentration of tumor DNA below the threshold required for either technique (NGS, 2–5%; RT-qPCR, 0.5%) may be rated as false negative [26].