BAX and carcinoma: However, Patro et al. [16] and Bhattacharyya et al. [17] reported that the photosensitizing effect of coralyne to ultraviolet A radiation, observed in several human carcinoma cell lines (A549, MCF7, A431 and MDA-MB-231), was associated with the increase in DNA double strand breaks and activation of the ATR-p38 MAPK-BAX pathway.