Recently, Wang C et al. reported that the high yields of photo-induced 1O2 by β-alanine modified gadofullerene nanoparticles (GFNPs) can lead to the destruction of the tumor vascular endothelial adherent junction protein-VE cadherin and the decrease of tumor vascular endothelial cells-CD31 proteins, inducing the rapid tumor necrosis [16]. The gene discussed is PECAM1; the disease is neoplasm.