In addition, Gd@C82(OH)22 affects the epigenetic regulation of human pancreatic cancer metastasis and suppresses pancreatic cancer cell invasion and metastasis by down-regulating metastasis-related protein 1 (MTA1), HDAC-1, HIF-1R and MMP-2/9 and up-regulating reversion-cysteine protein with the Kazal motif (RECK) expression [77,78]. This evidence concerns the gene MMP2 and pancreatic neoplasm.