Additionally, pyrrolidinium fullerene is exemplified for affecting tumor cell growth and inducing apoptotic cell death of cells mutated on JAK2 V617F by depletion of apoptosis signal-regulating kinase 1 (ASK1) and inactivation of c-Jun N-terminal kinase (JNK) pathway, which illustrates resistance to multiple anti-tumor drugs [107]. This evidence concerns the gene MAP3K5 and neoplasm.