INS and type 1 diabetes mellitus: Randomized controlled trials (RCTs) exploring the pharmacokinetic (PK) and PD properties of bolus insulins in patients with type 1 diabetes mellitus (T1DM) have demonstrated that compared to RHI, the RAIAs, aspart, lispro, and glulisine demonstrate an earlier onset of action, higher peak, shorter duration of action, and a greater glucose-lowering effect [81,82,83].