CRP and adenocarcinoma: Yeh et al. [88] examined the utility of immunohistochemical staining for CRP in the differential diagnosis of ICC, other adenocarcinomas, and metastatic liver tumors and reported that the sensitivity and specificity for diagnosing ICC were 75.7% and 91.1%, respectively, in tissue microarray, while they were 93.3% and 88.2%, respectively, in whole tissue sections.