Targeted agents against the vascular endothelial growth factor (VEGF) pathway have been particularly promising in combination with immune checkpoint inhibitor therapies, including axitinib with pembrolizumab for metastatic RCC and bevacizumab with atezolizumab in unresectable hepatocellular carcinoma (HCC) [74,75]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.