In contrast, a recent report by Fumagalli and colleagues reported that the majority of disseminating mouse CRC cells that seed liver metastases are Lgr5−, while metastatic outgrowth depends on the reappearance of Lgr5. They concluded that this plasticity occurs independently of microenvironmental factors and that Lgr5+ cells are essential for the growth, but not the establishment, of metastases. The gene discussed is LGR5; the disease is colorectal carcinoma.