LGR5 and neoplasm: Molecular and genetics studies using intestinal organoids have also been focused on RasGRP1, which acts as a tumor suppressor in the context of aberrant WNT signaling by inhibiting EGF-driven proliferation [78], and on YAP, a transcriptional activator of the Hippo pathway that when overexpressed has tumor suppressor activity by downregulating Wnt and Lgr5+ cell reprograming [79].