In the GBM mouse model, the overexpression of Romo1 in bone marrow cells was found to significantly inhibit the immune response within tumor microenvironment, and the overexpression of Romo1 resulted in the pro-tumoral macrophage polarization of bone marrow derived macrophages (BMDMs) through the mTORC1 signaling pathway. The gene discussed is ROMO1; the disease is glioblastoma.