EZH2 suppression in GBM cells can remodel microglia immune functions, resulted in significant increase of anti-tumoral macrophage markers (TNFα and iNOS) and decrease of a pool of pro-tumoral macrophage markers, ameliorated phagocytic capacities of microglia, and declined microglia proliferation (with addition of TGFβ2 antibodies) to co-incubated GBM cells with EZH2 inhibition. This evidence concerns the gene TGFB2 and glioblastoma.