EGFR and epidermal growth factor variant III (EGFRvIII) cooperate to induce macrophage infiltration via upregulation of the chemokine CCL2, and KRAS was a critical signaling intermediate for the EGFR- and EGFRvIII-induced expressions of CCL2 in glioma cells [25]. This evidence concerns the gene CCL2 and central nervous system cancer.