FX is secreted in the tumor microenvironment and increases the phosphorylation and activation of the extracellular signal-related kinase (ERK)1/2 and AKT in macrophages, exhibiting a potent chemotactic capacity to recruit macrophages and promoting macrophages toward pro-tumoral subtype polarization, thus accelerating GBM growth. The gene discussed is AKT1; the disease is glioblastoma.