Abnormalities in the epigenetic regulator Tet methylcytosine dioxygenase 2 (TET2) and Enhancer of zeste homolog 2 (EZH2) could induce CIN through the deregulation of histone modifications, which alters the chromatin structure and affect gene expression [164,165,166]. This evidence concerns the gene EZH2 and cervical squamous intraepithelial neoplasia.