Differential expression of miR-29b has been associated with various disorders including fibrotic diseases, cancers, and neurodegenerative diseases via regulation of ECM proteins and pathways targeting collagens, fibrillins, and elastin [100].The TME of colon tumors have shown increased antitumor activity in EA compared to AAs [101] with lower density of CD8+T cells, macrophages and B cells [21]. The gene discussed is CD8A; the disease is cancer.