The TME actively participates during the development and progression of many types of cancer through the involvement of a range of its cellular components including cancer associated fibroblasts (CAF), endothelial cells, pericytes, immune-inflammatory cells, as well as non-cellular extracellular matrix (ECM) components such as collagen, fibronectin, and laminin [23,24,25]. The gene discussed is LAMB2; the disease is cancer.