GSDMD and cancer: Table 3 summarises the significant variants. In the analysis of cancer (rPDAC + nrPC) vs. CP, three variants in the genes GSDMD and B4GALT5 showed a high association with pancreatic cancer in its two profiles (rPDAC and nrPC). In the gene GSDMD, one variant was significantly associated with cancer and another with CP. Wang et al. discuss GSDMD’s potential as a cancer target due to its role in pyroptosis gasdermin mediated programmed cell death [32]. It is highly connected with the CASP gene family (see Figure S1_6a), which is strongly related to the poor prognosis of pancreatic cancer [33].