PTGS2 and early-onset autosomal dominant Alzheimer disease: Among the neuronal gene targets of NF-κB in the CNS, and those relevant to the Alzheimer disease (AD) brain, are the following: brain-derived neurotrophic factor (BDNF), copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), calcium-calmodulin kinase II (CaMKII), postsynaptic density protein-95 (PSD-95), early growth response (Egr) factors, and cyclo-oxygenase-2 (Cox-2) [22].