Using bulk and single cell RNA sequencing, we identified 17 genes (e.g., KIAA1199, CDH3, GUCA2B, LGALS4, CA7, NR3C2, ABCG2, AQP8, etc.)including several metabolic genes (HSD11B2, NR3C2, ABCG2, CA7) associated with CRC pathophysiology. Here, CDH3 is linked to colorectal carcinoma.