Using bulk and single cell RNA sequencing, we identified 17 genes (e.g., KIAA1199, CDH3, GUCA2B, LGALS4, CA7, NR3C2, ABCG2, AQP8, etc.)including several metabolic genes (HSD11B2, NR3C2, ABCG2, CA7) associated with CRC pathophysiology. The gene discussed is AQP8; the disease is colorectal carcinoma.