Using bulk and single cell RNA sequencing, we identified 17 genes (e.g., KIAA1199, CDH3, GUCA2B, LGALS4, CA7, NR3C2, ABCG2, AQP8, etc.)including several metabolic genes (HSD11B2, NR3C2, ABCG2, CA7) associated with CRC pathophysiology. Here, HSD11B2 is linked to colorectal carcinoma.