In addition, data from other cancer types suggest several more putative mechanisms of resistance [60]: CDK4/6 overexpression [61], p16 amplification [62,63], upregulation of FGFR pathway [64,65], alteration of Hippo pathway [66], activation of CDK2 [67,68], autophagy [69], and epigenetic alterations [70,71]. The gene discussed is CDK4; the disease is cancer.