While MUF, MITA1 or PTENP1 (phosphatase and tensin homolog pseudogene 1) [96] lack validation in HCC tissues (Figure 3), other lncRNAs such as miR503HG, CASC2, ZFAS or lncRNA-ATB have validated correlations with overall survival (OS) and importantly, with micro and macrovascular invasion or portal vein tumor thrombus (PVTT), one of the first events in intrahepatic dissemination (Figure 4). This evidence concerns the gene PTENP1 and hepatocellular carcinoma.