BMPR1A and hepatocellular carcinoma: Similarly, lncRNA HAND2-AS1 (heart and neural crest derivatives expressed 2- antisense RNA 1) recruits the INO80 chromatin-remodeling complex to the promoter of BMPR1A (BMP (bone morphogenetic protein) receptor type 1A), thereby inducing its expression and leading to the activation of BMP signaling which activates the initiation of HCC [49].