CASC2 and hepatocellular carcinoma: Several other studies have found lncRNAs to promote or protect against metastasis in HCC cells by less frequent mechanisms involving regulatory signaling pathways such as Wnt-β-catenin (lncRNA MUF) [89], NF-κB (lncRNA miR503HG (MIR503 host gene)) [87] or novel metastasis-related factors such as FBXW7 (lncRNA CASC2 (circulating cancer susceptibility 2)) [40] with varying degrees of evidence of clinical relevance.