In OS, MSCs establish a metabolic coupling with tumor cells [13], and a paracrine communication mediated by pro-tumorigenic exosomes [14] and cytokines (IL6, IL8, and CCL5) [15,16,17,18,19] that eventually leads to the promotion of the stem-like subsets of OS, resulting in increased clonogenicity, migration, stemness, and chemoresistance [20,21]. Here, CXCL8 is linked to neoplasm.