We have recently developed spherical polymeric nanoparticles (SPN) encapsulating curcumin (SPN-curc), and demonstrated their ability to effectively diminish the vascular deposition of circulating tumor cells (CTCs) from a highly metastatic breast cancer cell line [51], to prevent tumor growth in combination with conventional chemotherapeutic molecules [52], and to counteract amyloid-β fibrils-induced inflammation [53]. Here, PPIB is linked to neoplasm.