GNAT3 and hepatocellular carcinoma: More interestingly, higher ratios of taurine-conjugated over glycine-conjugated major primary and secondary bile acids, specifically the TCDCA/GCDCA ratio and the TDCA/GDCA ratio, were associated with significantly higher risk of HCC, after adjustment for potential confounders, suggesting that the altered conjugation process may contribute to the development of HCC on top of their levels.