Ectopic MSX1 expression in melanoma cells increased their ability to migrate, downregulated the expression of MITF, zinc finger E-box binding homeobox 2 (ZEB2), and E-cadherin, and increased the expression of WNT5A and zinc finger E-box binding homeobox 2 (ZEB1) instead, whereas MSX1 downregulation decreased migration and formation of liver metastases in a xenograft mouse model [67]. The gene discussed is MSX1; the disease is melanoma.