TIGIT is enriched in PD1highCD8+TILs of HCC patients, and this subset represents the most dysfunctional and exhausted CD8+TIL phenotype and dual blockade of TIGIT and PD-1 improved the cytotoxic potential of CD8+ TIL in HCC patients [143]. The gene discussed is PDCD1; the disease is hepatocellular carcinoma.