Genome-wide and targeted DNA methylation analysis has shown that vitamin B12 deficiency in cultured human adipocytes leads to hypomethylation of the promoter regions of genes related to cholesterol biosynthesis, low density lipoprotein receptor (LDLR) and sterol regulatory element binding protein 1 (SREBF1), leading to an increase in their expression [127]. This evidence concerns the gene SREBF1 and vitamin B12 deficiency.