CASP3 and neoplasm: In summary, overall results showed reduced growth of the GBM 8401 cell xenograft tumor, including the reduction of the tumor volumes and weights by DMC through the induction of apoptosis, based on markedly decreased Bcl-2 and XIAP but significantly increased the cleaved caspase-3 and BAX in tumor tissues from the immunohistochemistry of tumor sections in the DMC treatment groups.