At least one of three autoantibodies (GAD-65, IA2, or ICA) was detected in 14.3% of healthy patients (n = 28), in 33.3% of APS-2 patients without a T1D diagnosis (n = 25), in 30.0% of patients with T1D (n = 20), in 42.9% of APS-2 patients with a diagnosis of T1D (n = 14), and in 35.3% of APS-1 patients without a diagnosis of T1D (n = 17) (Figure 5a). This evidence concerns the gene GAD2 and autoimmune polyendocrinopathy.