Since our study included patients over 18 years of age, the data obtained confirm the following results of previous studies: autoantibodies against type I interferons can be detected in adulthood, as well as in childhood [35], and titers of autoantibodies against IFN-ω, IFN-α-2a and IL-22 are almost always initially high and persist for decades after the onset of APS-1 [9]. The gene discussed is IFNA2; the disease is autoimmune polyendocrine syndrome type 1.