The aims of this study were (1) to investigate the prevalence of laryngeal H.pylori infection in a prospective case series of patients with newly diagnosed laryngeal lesions including VP, precancerous VFL, and laryngeal cancer in our hospital, (2) to investigate the expression of E-cadherin and CD1d of the larynx in this population, and (3) to elucidate the impact of laryngeal H. pylori infection on the development of laryngeal cancer across countries by performing a systematic review on the topic. This evidence concerns the gene CDH1 and laryngeal carcinoma.