AR and Familial prostate cancer: The PROPHECY (Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer) study combined the above two CTC AR-V7 detection assays: CTC AR-V7 mRNA assay [36,37] and CTC nuclear-specific AR-V7 protein assay [54,55].