EP300 and posterior cortical atrophy: Inhibition of p300/CBP by small molecule inhibitors has been shown to suppress PCa growth by several mechanisms, such as abrogation of phosphorylated CREB1 and p300/CBP interaction (compound names: SGC-CBP30 and C646) [81] and inhibition of AR/AR-Vs signaling (compound name: CCS1477) [68].