miR-320 has been confirmed as a microRNA correlated with metastasis and invasion, particularly in colorectal cancer, glioblastoma, NSCLC, and breast cancer (BC) cell lines by targeting crucial genes to decrease metastatic potential, such as G protein subunit alpha i1 (GNAI1), early growth response 3 (EGR3), and E74 like ETS transcription factor 3 (ELF3) [37,54,55]. The gene discussed is EGR3; the disease is breast carcinoma.