Polygenic non-familial hypercholesterolemia includes single nucleotide polymorphisms (SNPs) in several genes, involving common genes (LDLR, PCSK9) as well as less frequent genes, such as the ATP-binding cassette sub-family G member 8 gene (ABCG8) or cadherin EGF LAG seven-pass G-type receptor 2 gene (CELSR2) [13]. This evidence concerns the gene PCSK9 and familial hypercholesterolemia.