Hence, in agreement with the majority of studies published to date, we too did not observe any relationship between markers of collagen type I and III synthesis and degradation (PICP, PIIINP, CTIP) and fibrosis-controlling factors (CT-1, GDF-15 and PDGF) with replacement or interstitial fibrosis in our large and contemporary cohort of DCM patients. Here, CTF1 is linked to familial dilated cardiomyopathy.