An NT-proBNP increase of 500 pg/mL was related to ECV elevation by 2.6%, along with an increase of hs-TnT of 1 ng/mL by 8.31%, with adjustments for age, NYHA class, presence of atrial fibrillation and ventricular arrhythmias, uric acid, and cholesterol LDL. The gene discussed is NPPB; the disease is Ventricular arrhythmia.