CD4 and allergic asthma: The essence of these investigations was to identify whether all these therapeutic strategies, regardless of the inhibitory effect on the clonal expansion of CD4+ Teff cells in the MLNs, have the potential to break the pathogenesis of allergic asthma at its later stage by abolition and/or induction of the production by T cells of important cytokines promoting and/or inhibiting, respectively, the development of the disease.