CXCR4 and cancer: Specifically, the low expression of uL3 is associated with EMT transition, which results in a more aggressive and invasive cancer phenotype [37], whereas the enhanced expression of mS40 leads to the induction of C-X-C Motif Chemokine Receptor 4 (CXCR4) expression and, consequently, the upregulation of twist-related protein 2 (TWIST2) and the repression of epithelial markers [90].