We recently generated a bag3 (BCL2 associated athanogene 3) DCM model and a lamp2 (lysosomal-associated membrane protein 2) hypertrophic cardiomyopathy (HCM) model [33,34], demonstrating that different types of inherited cardiomyopathies can be created in this efficient vertebrate model. The gene discussed is BAG3; the disease is hypertrophic cardiomyopathy.