SNPs in the ANXA2, TEK and TGFBR3 gene loci were associated with stroke risk [32,45,46,47], the TGF-β/BMP pathway is associated with several SCD subphenotypes [48,49,50], while polymorphisms within the UGT1A1 are associated with increased serum bilirubin levels and cholelithiasis [51]. This evidence concerns the gene TEK and cholelithiasis.