The percentage of tumor cells with nuclear IRS-4 was 69.9 ± 3.2%, followed by nuclear PCNA 52.1 ± 7.8%, nuclear Ki-67 6.1 ± 1.1% (Figure 3A), and finally pH3 with only 1.3 ± 0.2% (Figure 3A). Here, IRS4 is linked to neoplasm.