In this context, MCUR1-dependent mitochondrial Ca2+ uptake has been reported to stimulate in vitro invasion and in vivo metastasis by promoting EMT via the ROS/Nrf2/Notch pathway and Snail transcription, pointing to MCUR1 as a potential therapeutic target for hepatocellular carcinoma treatment [103]. Here, MCUR1 is linked to hepatocellular carcinoma.