CYP2C19 and schistosomiasis: Considering the racemic praziquantel (PZQ), the drug of choice for the treatment of schistosomiasis, the metabolism of (R)-PZQ was mainly catalyzed by CYP1A2 and CYP2C19, whereas the metabolism of (S)-PZQ was mainly by CYP2C19 and CYP3A4.