AD-related cytokines and chemokines such as IL-1β, IL-4, IL-6, IL-8, TSLP, TNF-α, and MCP-1 are expressed and secreted by mast cells [16,30,31], which can stimulate eosinophils and keratinocytes and activate Th2 cells [32]. The gene discussed is IL1B; the disease is Alzheimer disease.