PCSK9 and atherosclerosis: Accordingly, in an atherosclerosis-prone mouse model, the deletion of the PCSK9 gene, independently of LDLR, reduced the expression of adhesion molecules from EC, such as ICAM-1, and chemotactic factors, e.g., MCP-1 and MCP-3, all promoting monocyte adhesion and infiltration into the vessel wall [84].