PCSK9 and Sepsis: PCSK9 overexpression exacerbates the hypercoagulable and pro-inflammatory states in early sepsis, a complex disease characterized by organ dysfunction along with systemic activation of inflammation and coagulation, as demonstrated in experimental models of mice overexpressing PCSK9 [47,139] and findings on humans [140]. The gene discussed is PCSK9; the disease is Sepsis.