In iCCA, the most frequent alterations were tumor protein 53 (TP53), CDKN2A/B, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), AT-rich interactive domain-containing protein 1 (ARID1), and IDH in 27%, 27%, 22%, 18%, and 16% of tumors respectively. This evidence concerns the gene KRAS and infantile convulsions and choreoathetosis.