To evaluate the potential interplay between IL1RA and IL1B in the context of bladder cancer cell invasion, we first identified the release of sIL1RA in the supernatant of RT4 and UROtsa cells (endogenous IL1RA) as well as of T24-IL1RA (ectopic IL1RA). The gene discussed is IL1B; the disease is urinary bladder carcinoma.