FLT3 and acute myeloid leukemia: Following these promising data, a randomized, placebo-controlled, double-blind phase II trial (the SORMAIN trial), enrolled 83 adult patients with FLT3-ITD-positive AML in complete hematologic remission after HCT who were randomly assigned to receive for 24 months either the multitargeted and FLT3-kinase inhibitor Sorafenib (n = 43) or placebo (n = 40 placebo) [46].