Although some subtype-specific differences have been reported, the majority of studies on Sdc-1 expression have assigned a negative prognostic and predictive value for high Sdc-1 expression in breast cancer, suggesting that the inhibition of Sdc-1 expression and/or function could be a therapeutic approach to impair breast tumor progression [6,8,11,12,13,14]. Here, SDC1 is linked to breast cancer.