Our finding of a reduced expression of the miRNA miR-10b both in Sdc-1-depleted and HA-treated breast cancer cells may serve to explain this effect in MDA-MB-231 cells, as it was recently shown that miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation [47]. This evidence concerns the gene SDC1 and breast carcinoma.