Remarkably, signaling pathways associated with regulating the pluripotency of stem cells, cell cycle, apoptosis, focal adhesion including PI3K-Akt, Rap1, EGFR, Ras, MAPK, and proteoglycans in cancer were enriched, as well as melanoma and bladder cancer (Figure 8E and Table S1). This evidence concerns the gene AKT1 and urinary bladder carcinoma.