NKX2-5 and cyclic hematopoiesis: However, it still remains to be determined if these and other documented monoallelic NKX2-5 VUS in CH patients, i.e., p.(Ser139Asn) [6], p.(Arg143Gln) [35], p.(Pro211Leu) [34], and p.(Asp226Asn) [7], could play roles as genetic susceptibility factors, even in a digenic or polygenic model [3,42].