Evaluation of CNVs by multiplex ligation-dependent probe amplification (MLPA) identified whole-exon heterozygous deletions in PAX8, TSHR, and FOXE1 as being relevant pathogenic changes in 11% of CH-TD Polish patients [15], but this has not been replicated in other populations [7,16]. This evidence concerns the gene TSHR and cyclic hematopoiesis.