We assembled a set of 265 genes chosen from the published literature for their role in chordoma physiopathology, including TBXT super-enhancer associated genes and chordoma essentiality genes in CRISPR-CAS9 screens (26), notochord related genes (21), mesoderm commitment pathway (166), SWI/SNF complex (18), PI3K/Akt/mTOR pathway (33) and Sonic Hedgehog pathway (28). This evidence concerns the gene AKT1 and chordoma.