AKT1 and chordoma: Genes with rare germline variants enriched in chordoma cases were involved in signaling pathways and physiopathological processes that are affected in chordoma at the somatic level (e.g., notochord development, PI3K/AKT/mTOR and SWI/SNF pathways), which underscores the importance of pathway/process-level analysis of germline alterations to identify potentially novel genes.