The overall survival analysis based on the LGG GBM cohort (p value < 0.001; Figure 1G), the LGG cohort (p value < 0.001; Figure 1H) and the GBM cohort (p value < 0.001; Figure 1I) suggests that high CALD1 serves as promoter of glioma. This evidence concerns the gene CALD1 and central nervous system cancer.